Posted in: Other in Vermont | Posted: |
Job Description
Key Responsibilities
Responsible for developing, optimizing & executing new analytical methods & techniques to characterize complex proteins/glycoproteins, antigens & novel protein-based therapeutics.
Work within multi-disciplinary project teams & act as a lead analytical & biophysical resource to guide development & advance pipeline.
Resolve key project challenges by effectively utilizing available analytical tools, information & technical expertise.
Develop, optimize & execute new analytical methods & techniques to characterize complex proteins/glycoproteins, antigens & novel protein-based therapeutics.
Strategically advance scientific expertise within the Analytics group by conceiving & executing novel scientific research & development efforts to address project challenges & provide novel insights.
Demonstrate leadership by advising & sharing knowledge & expert opinions with peers & senior management.
Contribute to research that leads to peer-reviewed publications, reports & external presentations.
Employ experience in protein analytical & biophysical characterization to discern protein critical quality attributes (physiochemical properties, post-translational modifications) & better understand protein structure-function relationships.
Work in cross-functional teams with scientists across functions & therapeutic areas (Virology, Immunology, Oncology & Neuroscience) to discover & develop next generation biologics through interrogation & engineering of protein attributes across both targets and therapeutic molecules.
Responsible for utilizing verbal & written skills & the ability to clearly present scientific concepts & results for functional scientific & non-scientific leaders.
Employ experience with in-depth protein analytical characterization using a variety of techniques such as LC-MS/MS, SE-HPLC, CE, CD, NMR, TEM, SE-HPLC-MALS, DLS, iCIEF.
Employ experience utilizing various software such as Thermo Xcalibur, BSI PEAKS, PMI Byologic, Wyatt Astra, Wyatt Dynamics, MS Word, MS Excel, MS Ppt, PRISM, & ImageJ.
Responsible for demonstrating proficiency with various chromatographic techniques, capillary electrophoresis methodologies & in-depth biophysical characterization.
Responsible for preparation and characterization of disease-relevant proteins in defined morphological states. Employ experience in guiding recombinant protein expression & purification.
Employ experience with protein labeling & conjugation, as well as protein formulation & remediation. Prepare written documentation, reports & presentations of work & strategies.
Work on the selection of targets or variants for therapeutic development & include the design, engineering & characterization of resulting therapeutics & their mechanisms of action.
Employ experience with routine mass spectrometry workflows, including intact & subunit analysis.
Responsible for project driven initiatives that will require scientific exploration & experimentation as well as close collaboration with scientists across the organization.
Responsible for new technology development by expanding analytical expertise & custom assays, project leadership, hypothesis-driven experimentation, orientated towards discovering & developing novel therapeutics.